Director, Business & Operations – US Commercial

Strategic & Operational Partnership

• Serve as a trusted thought partner to the SVP, Head of US Affiliate, translating affiliate strategy and priorities into clear, actionable, and measurable operating plans as Dyne prepares for its first U.S. product launch. - Support the US Affiliate Leadership Team with structured problem solving, prioritization, and follow‑through across key initiatives. - Anticipate organizational needs and proactively bring recommendations, options, and solutions to leadership. Business Operations & Operating Rhythm

• Establish and manage the operating rhythm for the US Affiliate, including leadership meetings, business reviews, planning cycles, and governance forums. - Drive clarity on goals, ownership, timelines, and success metrics across affiliate initiatives. - Develop and maintain dashboards and tracking tools that provide transparency into performance, risks, dependencies, and decision points. Budget, Financial Planning & Resource Management

• Support development and management of the US Affiliate budget in close partnership with Finance, including annual planning, forecasting, tracking, and variance management. - Support headcount planning, resource allocation, and investment prioritization to ensure alignment with affiliate and enterprise objectives. - Prepare budget materials, analyses, and recommendations for affiliate leadership and enterprise review forums. Cross‑Functional & Enterprise Initiatives

• Lead and coordinate high‑priority, function‑wide and cross‑functional initiatives impacting the US Affiliate. - Act as a central point of integration between the US Affiliate and partner functions to ensure alignment and execution. - Track initiative progress, identify risks, and escalate issues with proposed solutions. Leadership Enablement & Execution

• Drive coordination across HQ and field‑based roles spanning Commercial, Medical, and partner functions to maintain momentum and alignment on priority initiatives. - Design and manage the US Affiliate “Cadence of the Business,” including Leadership Team meetings, offsites, business reviews, and short‑ and long‑term planning cycles. - Serve as a leader for high‑priority initiatives that do not have a natural functional home (e.g., ways of working, launch KPI management, executive reporting). - Support change management and organization‑wide communication for new processes, initiatives, and ways of working. Vendor, Contract & External Partner Management

• Oversee vendor strategy and management for the US Affiliate, including agency partners, consultants, and other external service providers. - Partner with Legal, Finance, and Procurement to manage contracts, statements of work, renewals, and compliance. - Ensure vendors are delivering against scope, timelines, and value expectations. Education and Skills Requirements:

• Bachelor’s degree required; advanced degree (MBA or equivalent) preferred. - 10+ years of progressive experience in commercialization strategy, commercial operations, program management, or related roles within biotechnology or pharmaceuticals, or relevant experience from a biotech or life sciences consulting firm focused on commercialization or commercial planning. - Experience supporting senior leaders and leadership teams in high‑growth or launch‑stage environments. - Demonstrated experience with budget management, financial planning, and vendor/contract oversight. - Strong cross‑functional leadership skills with the ability to influence without formal authority. - Exceptional written and verbal communication skills; able to synthesize complexity into clear, executive‑ready thinking. - Highly organized, detail‑oriented, and comfortable managing multiple priorities simultaneously. - High integrity and discretion in handling sensitive and confidential information. #LI-Onsite

MA Pay Range

$196,000—$240,000 USD

The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education, experience, job-related knowledge, and demonstrated skills. The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.