Associate Scientist, Delivery Sciences

Why Join Intellia? Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just "treat" people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together. Seeking a highly skilled and motivated Associate Scientist in Lipid Nanoparticle (LNP) Discovery to lead efforts in the production, scale-up and characterization of next generation lipid-based delivery systems for nucleic acid therapeutics. The successful candidate will play a key scientific role in advancing our delivery platform, working at the interface of formulation science and biology to advance our pipeline. Duties/Responsibilities Design, formulate, and characterize lipid nanoparticle (LNP) systems for nucleic acid delivery across early research and preclinical development stages Develop and optimize formulation processes, including microfluidic mixing and scale-up approaches (e.g., TFF, ultrafiltration) Screen and evaluate novel ionizable lipids and LNP compositions; analyze structure–function relationships to improve delivery performance Deliver reproducible and impactful results under ambitious timelines, present results in cross-functional meetings to a broad audience. Interpret and summarize current literature, implement new features and functionality to improve delivery. Generate high-quality, reproducible data and maintain thorough documentation in electronic lab notebooks Interact with internal groups and external collaborators to supply formulations for in vitro and in vivo studies. Independently design and analyze preclinical studies. Requirements Skills/Abilities Extensive hands-on experience with LNP scale-up, process development and analytical techniques is a plus Experience with nanoparticle characterization techniques (e.g., DLS, zeta potential, fluorescence-based assays such as Ribogreen, chromatography) Organized, detailed oriented, and self-starter who continuously seeks to improve existing laboratory methods and processes. Effective verbal and written communication skills Education / Certifications Bachelors or Master's in Pharmaceutical Sciences, engineering, chemistry or related discipline with at least 4+ (Bachelor's degree) or 2+ (Master's degree) years of post-graduation experience, preferably in industrial drug discovery setting Experience Knowledge of lipid chemistry, ionizable lipid design, or bioconjugation techniques. Experience supporting in vivo studies or translating formulations from research to preclinical scale Expertise in TFF and buffer exchange. Data analysis and communication. Troubleshooting and process improvement. Good communication skills. Strong work ethic. EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Applications are accepted on a rolling basis, and will continue to be accepted until the position is filled at which point the position will be taken down. The base salary for this position is expected to range between $106,200.00 - $129,800.00 USD per year. The salary offered is determined based on a range of factors including, but not limited to, relevant education and training, overall related experience, specialized, rare or in-demand skill sets, internal comparators and other business needs. Upon joining Intellia, your salary will be reviewed periodically and additional factors such as time in role and performance will be considered. Intellia may change the published salary range based on company and market factors. Additional compensation includes a performance-based annual cash bonus, a new hire equity grant, and eligibility to be considered for annual equity awards the value of which are determined annually at the Company's discretion. For more information about Intellia's benefits, please click here. At Intellia, we are committed to solving the complex challenges of making CRISPR/Cas9-based medicines a reality for patients suffering from genetic diseases and to create novel engineered cell therapies for immuno-oncological and autoimmune diseases.