Scientist II, Conjugation Development

• Optimize and troubleshoot multi-step syntheses of protein-polysaccharide conjugates. - Purify polysaccharides and conjugates using a variety of methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF)

• Analyze polysaccharides and conjugates with a variety of analytical methods. Develop new laboratory workflows and analyses beyond established procedures when appropriate. - Advise team members on experimental design, interpretation of results, and troubleshooting. - Model and train team members on best practices for adherence to protocols and data management. - Serve as a subject matter expert during tech transfer of conjugation processes to contract manufacturing organizations. - Maintain highly organized records to enable optimization and assessment of reproducibility. - Attend team meetings ready to provide updates on conjugation development progress. ### Requirements:

• PhD in chemistry, biochemistry, or related field with minimum 2 years of industry experience, or combination of industry and postdoctoral research; MS with minimum 7 years industry experience, or BS with minimum 10 years of experience industry. - Strong biochemistry and organic chemistry knowledge base underpinning several years’ experience preparing bioconjugates. - Proficiency with small- and large-scale techniques for purification of bioconjugates, including tangential flow filtration. - Proficiency in a variety of techniques for bioconjugate analysis such as colorimetric assays, HPLC, and SEC-MALS. - Sufficient knowledge of analytical principles to develop fit-for-purpose analytical methods as needed and provide cross-functional feedback on draft analytical methods. - Experience with Design of Experiments is desirable. - Experience with chemical modification of polysaccharides is desirable. - Experience implementing and/or using electronic notebooks is desirable. - Attention to detail and excellent organizational skills. - Strong interpersonal skills; ability to communicate effectively both verbally and in written formats. - Self-starter; ability to work in a fast-paced, cross-functional environment and collaborate effectively with other team members. - Enthusiasm to learn the new skills and techniques necessary to tackle problems outside of current area of expertise. - This is lab based role that requires an onsite presence. Reports to: Associate Director, Conjugation Development

Location: San Carlos, CA

Compensation:

The compensation package will be competitive and includes comprehensive benefits and an equity component. Salary Range: $146,000 - $170,000 (SF Bay Area).