Senior Payroll and Accounting Specialist

• Manage the full-cycle payroll process, including data entry, tax withholdings, and benefits deductions, etc. - Ensure all payroll activities align with federal, state, and local tax regulations, including the proper handling of withholdings and filings. - Perform regular audits of payroll data and reconcile payroll bank accounts to ensure accuracy and identify discrepancies. - Coordinate with HR to ensure accurate deductions for health insurance, retirement plans (401k), and other voluntary benefits. - Act as the primary point of contact for staff regarding pay-related inquiries, resolving issues related to paychecks or tax forms with high confidentiality. - Identify opportunities to streamline payroll workflows and improve the efficiency of the payroll software or HRIS. - Prepare and post monthly journal entries for payroll accruals, benefits, taxes, and other standard corporate expenses. - Maintain T&E system including syncing to the Company’s ERP and reviewing expense transactions for compliance with Company policies. - Assist in the preparation of monthly and quarterly financial statements by ensuring all payroll-related expenses are accurately categorized. - Maintain and document internal controls (such as SOX compliance procedures) to ensure the integrity of financial reporting and prevent fraud. - Facilitate the issuance of new equity awards (RSUs, Stock Options, or ESPP) by ensuring all grant agreements are properly executed and recorded in the equity platform. - Monitor vesting schedules and process stock option exercises, ensuring the accurate flow of data between the equity platform and payroll for tax withholding. - Other duties as assigned. Ideal Candidate:

• Bachelor’s degree in Accounting or related field

• 5+ years of payroll and accounting experience

• Experience managing payroll and tax withholdings across multiple states. Experience with international locations is a plus. - Proficiency in payroll/HRIS and equity management platforms (i.e. Rippling, Fidelity, E*TRADE)

• Solid understanding of the lifecycle of various equity vehicles, including RSUs, NSOs, ISOs, and ESPPs. - A proven track record of handling highly sensitive executive compensation and employee financial data with total discretion. - Excellent organizational, analytical, prioritization and problem-solving skills in an environment of high volume of projects; detail-oriented

• Possesses a professional demeanor, discretion and judgment

• Ability to work effectively and establish and promote positive relationships

• Self-starter who possesses initiative and ability to work alone while capable of driving business results without significant supervision

• Must have schedule flexibility to meet the demands of monthly and quarterly close

• Excellent verbal and written communication skills

• Ability to work effectively with all employee levels and external contacts

What We Offer:

• Opportunity to work in a fast-paced, dynamic environment where you help shape the culture of our young company, contribute broadly to advance meaningful medicines, and learn quickly. - Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits. - Unlimited PTO
• Two, one-week company-wide shutdowns each
• Commitment to provide professional development opportunities. - Remote working environment with frequent in-person meetings to address complex problems and build relationships. The expected salary range offer for this role is $110,000 to $130,000. Actual pay offered may vary depending on job related knowledge, experience, education, and geographic location. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, gender, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non-job-related characteristics or other prohibited grounds specified in applicable federal, state and local laws. We also embrace differences in experience and background, and welcome diversity of opinions and thought with active recruitment designed to create a stronger and better Spyre that is focused on developing life-changing products for patients. Spyre Therapeutics, along with other biotech companies, has become aware of a surge in email scams targeting prospective job candidates within our industry. Please be aware that official recruiters at Spyre Therapeutics only use email addresses with the domain “@spyre.com.” We want to also emphasize that we never request candidates to make any purchases or divulge sensitive personal information via email. Please also be aware that all job postings will be listed on our website at spyre.com/careers/.