Senior Director, Enterprise Productivity Office Lead

Are you ready to shape an enterprise productivity agenda that frees capacity for science and care, while strengthening the performance of a dynamic rare disease business? This role leads a cross-functional office with a clear mandate: unlock measurable value, accelerate strategic priorities, and embed productivity as a core way of working across AstraZeneca. You will partner with senior leaders to align strategy, funding, and resourcing for the initiatives that matter most. From footprint optimization and automation to smarter operating models, you will connect enterprise-wide opportunities to tangible results in cost, speed, and quality. How will you rally diverse teams to deliver benefits that protect margins, create capacity, and ultimately improve patient impact? Accountabilities: Enterprise Productivity Strategy and Governance: Own and evolve the enterprise productivity strategy aligned to corporate and leadership priorities; secure alignment on scope, outcomes, funding, and resourcing. Strategic Enablement: Lead core focus areas across global footprint optimization, technology and innovation, automation and insourcing, and centralization to build scalable, efficient capabilities. Initiative Leadership: Identify high-value opportunities; lead enterprise-critical initiatives and support business-led efforts that require enterprise alignment, a consistent methodology, or acceleration. Cross-Functional Engagement and Change Enablement: Partner with global and functional leaders to embed productivity into business planning and day-to-day execution; foster a culture of innovation, smart risk-taking, and experimentation. Financial Impact and Reinvestment: Build robust business cases with clear KPIs; ensure initiatives deliver measurable outcomes such as cost savings, margin protection, and capacity release; track benefits through implementation. Governance and Portfolio Management: Lead steering committees and working groups; manage decisions, risks, and dependencies; maintain a clear initiative pipeline, prioritization, and quarterly planning cadence. Delivery Excellence: Define and plan new work, engage cross-functional teams, and drive milestones to completion on time; track benefits against baselines including efficiency gains and cycle-time reduction. Change and Adoption Outcomes: Partner with HR on change impact assessments, training, communications, and adoption tracking (completion rates, usage metrics, process compliance) to embed new ways of working. Continuous Improvement of EPO Ways of Working: Enhance templates, dashboards, and delivery playbooks; capture lessons learned to improve predictability, transparency, and delivery efficiency. Essential Skills/Experience: • Advanced degree in business, life sciences, engineering, data science, or related field; PhD or MS preferred. • 10+ years' experience in pharma/biotech or a related industry, leading enterprise-level initiatives with proven cross-functional delivery. • Experience implementing AI, digital, or data-driven solutions. • Strong program leadership, vendor management, and cross-functional influence at senior levels; change management and operating model design experience. • Essential: Experience leading enterprise-wide projects, transformation, or operating model initiatives. • Proven ability to operate at executive level, influencing prioritization and investment decisions with strong communication skills. • Strong track record delivering measurable productivity, cost, or efficiency outcomes. • Enterprise strategy, portfolio, and project management. • Productivity and operating model design expertise. Desirable Skills/Experience: • Experience in rare disease, specialty care, or complex, regulated healthcare environments. • Demonstrated success deploying automation and AI at scale, including business case development and benefit realization tracking. • Expertise in centralization, shared services, and insourcing models, including transition planning and change adoption. • Lean Six Sigma, Agile delivery, or similar continuous improvement credentials. • Executive-ready communication, with the ability to distill complex portfolios into clear decisions and actions. • Strong data literacy and familiarity with portfolio and performance dashboards. • Comfort operating in a global matrix with senior stakeholders across Finance, HR, IT, and Commercial; ability to balance pace with governance. • Willingness to travel to key hubs and sites as required. Why AstraZeneca: Join a team that blends the pace and curiosity of biotech with the scale and discipline of a global biopharma. Here, enterprise productivity is a catalyst for real-world impact: unexpected teams come together in the same room to reimagine how we work, combine cutting-edge digital and AI solutions with pragmatic operations, and translate ideas into outcomes patients can feel. You will be trusted to take bold, well-judged decisions and supported by leaders who value kindness alongside ambition—so you can stretch your capabilities, influence at the highest levels, and see the outcomes of your work in the speed, quality, and reach of therapies for people with unmet needs. Date Posted 22-May-2026 Closing Date 18-Jun-2026 Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form. For over three decades, patients and their caregivers have been at the center of everything we do. Every day, we are inspired to follow the science and think differently to create better outcomes for them and their families. Our mission is driven by understanding who they are as unique individuals, not solely defined by their diseases. We're a leading rare disease company with a diversified projects. Our pioneering legacy in rare diseases is rooted in being the first to translate the complex biology of the complement system into transformative medicines over the past three decades. Today, we continue to push the boundaries of science and deepen our understanding of rare diseases with patient-centricity at the core. This knowledge allows us to innovate and evolve into new areas where needs are unmet and provide an opportunity to help people fully live their best lives.