Posted Jun 1, 2026
Truveta provides unprecedented real-world data and real-time intelligence, powered by a dataset built with and owned by US health systems united in a mission of Saving Lives with Data. Together, we power breakthrough medical discoveries, accelerate regulatory-grade evidence, and improve patient care. Today, Truveta enables research on more than 130 million de-identified patients across the US. Achieving Truveta’s ambitious mission requires an incredible team of talented and inspired people with a special combination of health, software and big data experience who share our company values. Role Overview
We are looking for a Security Engineer for Microsoft 365 Security Administration to lead the security, governance, and protection of Microsoft 365 security and collaboration platforms, including Exchange Online, Microsoft Teams, OneDrive for Business, and Microsoft 365 Copilot. This role focuses on securing identities, protecting sensitive data, strengthening threat detection and response capabilities, and ensuring compliance with security best practices. You will work closely with IT and other security teams to improve security posture and drive the adoption of Microsoft security solutions. Responsibilities
Microsoft 365 Security Administration
Administer, configure, and maintain Microsoft 365 security and collaboration platforms, including Exchange Online, Microsoft Teams, OneDrive for Business, and Microsoft 365 Copilot
Manage and enforce security policies across Microsoft 365 services, including email protection, collaboration controls, data sharing, retention, and compliance settings
Configure and maintain Microsoft Defender for Office 365, Exchange Online Protection (EOP), Safe Links, Safe Attachments, anti-phishing, and anti-spam policies
Monitor Microsoft 365 environments for suspicious activity, unauthorized access, risky behavior, and security posture gaps
Administer secure collaboration and external sharing controls for Microsoft Teams and OneDrive for Business
Support secure deployment, governance, and operational oversight of Microsoft 365 Copilot, including data access controls, compliance considerations, and AI security best practices
Review and remediate Microsoft Secure Score recommendations and continuously improve Microsoft 365 security posture
Maintain tenant configuration standards, governance documentation, operational procedures, and security baselines
Ensure Microsoft 365 services comply with organizational security, privacy, retention, and regulatory requirements
Incident Response & Security Operations
Investigate and respond to Microsoft 365-related security incidents, including phishing, account compromise, malicious email activity, unauthorized sharing, and insider threats
Act as an escalation point for complex Microsoft 365 security and administration issues
Participate in incident response activities related to Exchange Online, Teams, OneDrive, Entra ID, and Microsoft Defender
Support audit, compliance, eDiscovery, and forensic investigations within Microsoft 365 environments
Maintain detailed documentation of incidents, remediation activities, and operational changes
Contribute to security awareness initiatives and help educate users on secure collaboration and Microsoft 365 best practices
Security Monitoring & Automation
Monitor Microsoft 365 security alerts, audit logs, and Defender incidents to identify and respond to threats in a timely manner
Develop and maintain reporting, dashboards, and alerting for Microsoft 365 security and operational visibility
Automate routine administrative and security tasks using PowerShell, Microsoft Graph API, and native Microsoft 365 automation capabilities
Support integration of Microsoft 365 logs and alerts into SIEM/SOAR platforms such as Microsoft Sentinel
Assist with development and tuning of alerting, policies, and workflows to reduce operational overhead and improve detection accuracy
Governance, Compliance & Collaboration
Partner with infrastructure, identity, compliance, and security teams to implement and maintain secure Microsoft 365 solutions
Support Data Loss Prevention (DLP), retention policies, sensitivity labels, and information protection initiatives across Microsoft 365 workloads
Assist with license management, service optimization, and adoption of Microsoft 365 security and compliance capabilities
Participate in Microsoft 365 governance reviews, audits, risk assessments, and remediation activities
Contribute to operational process improvements, documentation, and platform standardization efforts
Continuous Learning
Stay current on Microsoft 365 platform updates, security capabilities, emerging threats, and Microsoft security roadmap changes
Maintain awareness of evolving AI governance and security considerations related to Microsoft 365 Copilot and generative AI technologies
Key Qualifications
Be a part of building something special. Now is the perfect time to join Truveta. We have strong, established leadership with decades of success. We are well-funded. We are building a culture that prioritizes people and their passions across personal, professional, and everything in between. Join us as we build an amazing company together. Truveta is committed to creating a diverse, inclusive, and empowering workplace. We believe that having employees, interns, and contactors with diverse backgrounds enables Truveta to better meet our mission and serve patients and health communities around the world. We recognize that opportunities in technology historically excluded and continue to disproportionately exclude Black and Indigenous people, people of color, people from working class backgrounds, people with disabilities, and LGBTQIA+ people. We strongly encourage individuals with these identities to apply even if you don’t meet all of the requirements.
Don't want to apply yourself?
Our team writes your resume, applies for you, preps you for interviews, and negotiates your offer.
Browse Jobs
By Role
By City