Senior Scientist, Immune-Aging

AstraZeneca is seeking a Senior Scientist to join our growing T-cell Aging Unit and lead research focused on restoring immune function in aged populations. This role will pioneer research at the intersection of aging biology and immunology, translating findings into therapeutic interventions. The position primarily focuses on in vitro modeling and target validation. The successful candidate will also provide translational support by collaborating with external CROs and/or our in vivo pharmacology team to design in vivo studies and process animal tissues ex vivo to evaluate study endpoints. At AstraZeneca, you will have the opportunity to make a significant impact on the future of healthcare while working in a collaborative environment at the cutting edge of research. The ideal candidate will thrive in this setting and contribute to our continued growth as we build our evolving team. Key Responsibilities Target discovery and validation: Design and execute experiments to inform target identification and validation for age-related immune restoration. Aging mechanism studies: Implement experiments that distinguish immune cell-intrinsic aging from microenvironment-mediated changes. Strategy contribution: Contribute to the evolution of immune-aging strategy based on emerging insights and experimental findings. Data generation and communication: Generate high-quality data and present results to internal stakeholders and the external scientific community. Cross-functional teamwork: Work within multidisciplinary teams while maintaining flexibility in a dynamic research environment. Translational support: Collaborate with external CROs and internal in vivo pharmacology teams to support study design and evaluate in vivo endpoints through ex vivo tissue processing. Required Qualifications Education and experience: PhD in Immunology, Aging Biology, Cell Biology, or a related field, with 3-5 years of postdoctoral or industry experience in aging biology and immunology. Technical expertise: Proficiency in flow cytometry, immunological assays, and cellular and molecular biology methods; experience with in vitro and in vivo aging/immunology models. Scientific knowledge: Deep understanding of immune cell-intrinsic versus microenvironment-driven aging mechanisms. Scientific impact: Demonstrated publication record in peer-reviewed journals. Skills and capabilities: Strong analytical abilities for complex datasets; excellent written and oral communication skills; proven collaboration in team environments; highly self-motivated and adaptable to evolving priorities. Preferred Qualifications In vivo experience: Prior experience with basic in vivo procedures. Drug discovery experience: Experience in drug discovery or therapeutic development. Immune cell expertise: Expertise working with aging-affected immune cell populations, including T cells, NK cells, and myeloid cells. Therapeutic area knowledge: Knowledge of immuno-oncology therapeutic strategies. Biomarker understanding: Understanding of immune aging biomarkers and immune health assessment. About the Waltham Site Our Waltham, Massachusetts facility develops life changing small-molecule research in North America, with innovative laboratories at the Gatehouse Park BioHub, just west of the city center. Our BioHub facility, is a bold new R&D initiative, which fosters life science discoveries and the exchange of ideas. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration. With a shuttle bus to and from Alewife station, the location provides you the ability to work in the heart of one of the world's most vibrant research centers. Our Waltham site offers a variety of amenities to help book productivity and help keep our employees happy and engaged. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly designed, activity-based workspaces to suit a variety of working styles while increasing collaboration between teams and the greater research community. As AstraZeneca continues to put patients at the forefront of our mission, we are excited for our move to Kendall Square/Cambridge in 2026. Find out more information here: Kendall Square Press Release Ready to join us on this mission? Apply now! If you're curious to know more, please contact Bobbi Poole, our Talent Acquisition Partner. Competitive remuneration and benefits apply We offer a competitive Total Reward program including a market driven base salary, bonus and long-term incentive. We have a generous paid time off program and a comprehensive benefits package. The annual base pay for this position ranges from $116,284.00 - $174,426.00. Our positions offer eligibility for various incentives—an opportunity to receive short-term incentive bonuses, equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs, paid time off (i.e., vacation, holiday, and leaves), as well as health, dental, and vision coverage in accordance with the terms of the applicable plans. Date Posted 08-May-2026 Closing Date 28-May-2026 Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and employees. In furtherance of that mission, we welcome and consider applications from all qualified candidates, regardless of their protected characteristics. If you have a disability or special need that requires accommodation, please complete the corresponding section in the application form. AstraZeneca is a global, science-led, patient-focused biopharmaceutical company. We focus on discovering, developing and commercialising prescription medicines for some of the world's most serious diseases. But we are more than one of the world's leading pharmaceutical companies. At AstraZeneca, we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science, challenge convention and unleash your entrepreneurial spirit. To embrace differences and take bold actions to drive the change needed to meet global healthcare and sustainability challenges. There is no better place to make a difference in medicine, patients, and society. An inclusive culture where you will connect different thinking to generate new and valuable opportunities. Where you will find a commitment to lifelong learning, growth and development for all. Our Inclusion & Diversity (I&D) mission is to create an inclusive and equitable environment where people belong, using the power of our diversity to push the boundaries of science to deliver life-changing medicines to patients. Inclusion and diversity are fundamental to the success of our company, because innovation requires breakthrough ideas that only come from a diverse workforce empowered to challenge conventional thinking. We're curious about science and the advancement of knowledge. We find creative ways to approach new challenges. We're driven to make the right choices and be accountable for our actions. As an organisation centred around what makes us human, we put a big focus on people. Across our business, we want colleagues to wake up excited about their day at the office, in the field, or in the lab. Along with our purpose to bring life-changing medicines to people across the globe, we have a promise to you: to help you realise the full breadth of your potential. Here, you'll do work that has the potential to change your life and improve countless others. And, together with your team, you'll shape a culture that unites and inspires us every day. This is your life at AstraZeneca.